A gene panel comprises a defined selection of genes that are enriched and sequenced. With this method, it is possible to sequence many samples simultaneously with a high sequencing depth using next generation sequencing. Panel sequencing results in a manageable amount of data with a low proportion of underrepresented regions.
CeGaT has been using the concept of panel sequencing in genetic diagnostics since 2009. Based on our long-standing expertise, we can offer different predefined panels. Benefit from either PacBio’s long-read sequencing technology with HiFi reads or use the established short-read sequencing technology powered by Illumina. With our long-read panels, you can investigate genes involved in drug metabolism and therapeutic responses or genes that are difficult to sequence using short-read. For short-read panels, we are happy to assist you in generating and validating a custom panel design. If you are interested in predesigned short-read panels to characterize tumors, please check out our Comprehensive Tumor Profiling portfolio.
CeGaT Is the Best Partner for Sequencing Your Project
Our Commitment to You
Fast Processing
Turnaround time
≤ 15 business days
High Quality
Highest accuracy for all processes
Secure Delivery
Secure provision of sequenced data via in-house servers
Safe Storage
Safe storage of samples and data after project completion
Our Service
We provide a comprehensive and first-class project support – from selecting the appropriate product to evaluating the data. Each project is supervised by a committed scientist. You will have a contact person throughout the whole project.
Our service includes:
- Detailed project consulting
- Product selection tailored to your project
- Detailed bioinformatic evaluation of your data
- Detailed project report with information about sample quality, sequencing parameters, bioinformatic analysis, and results
Benefit from our dedicated support and accredited workflows.
Explore Our Product Portfolio for Panel Sequencing
We offer different Panel Sequencing (PAS) products to address a variety of research questions. Would you like to have bioinformatic analyses performed on your data in addition to the included deliverables? Each of our products can be supplemented with further services. We are happy to advise you.
HiFi PAS PGX | HiFi PAS Dark | PAS Flex |
Species | Species | Species |
Sequencing panel | Sequencing panel | Sequencing panel |
Sequencing platform | Sequencing platform | Sequencing platform |
Output | Output | Output |
Included deliverables | Included deliverables | Included deliverables |
If you are interested in Panel Sequencing to characterize tumors, please check out our Comprehensive Tumor Profiling portfolio.
Bioinformatics
For sequencing projects completed on our PacBio system, you will get the HiFi reads as clipped BAM files or FASTQ files. For short-read sequencing projects, you will receive demultiplexed FASTQ files. If you are interested in further bioinformatic analyses, feel free to contact us. If you design a custom panel with us, the data format for delivery and the individual data analysis will be defined according to your needs.
Technical Information
The PacBio platform enables us to sequence enriched DNA fragments with a length of 5-6 kb to generate HiFi reads. On this platform, we offer two panels designed by Twist:
- The HiFi PAS PGX panel targets 49 genes relevant to pharmacogenomics.
- The HiFi PAS Dark panel targets 389 genes that are difficult to sequence with short-read sequencing.
For short-read sequencing on our Illumina platforms, we support you in defining the target and validating your custom panel following the CAP and ISO:15189 quality standards approved for diagnostics. We suggest paired-end sequencing of CeGaT panel-enriched libraries (2 x 100 bp). If you require other sequencing parameters, please let us know! We can provide further solutions.
Gene Directory for HiFi PAS PGX & HiFi PAS Dark
Further Information about Panel Sequencing
Panel sequencing is a cost-effective and efficient way to investigate diseases like Mendelian diseases or cancer. With the predefined panels, specific genetic regions are targeted and enriched. These regions are associated with the phenotype or disease of interest. Thus, different panels are available at CeGaT.
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Contact Us
Do you have a question or are you interested in our service? Feel free to contact us. We will take care of your request as soon as possible.
Start Your Project with Us
We are happy to discuss sequencing options and to find a solution specifically tailored to your clinical study or research project.
When getting in contact, please specify sample information including starting material, number of samples, preferred library preparation option, preferred sequencing depth and required bioinformatic analysis level, if possible.
