Tumor Diagnostics Throughout Patient Care

From initial tumor profiling to therapy monitoring and follow-up: find the right molecular genetic analysis for your specific question

Molecular genetic analyses are a key component of modern tumor diagnostics and support you at every stage of patient care. We accompany you from genetic clarification at initial diagnosis to therapy recommendations, monitoring, and follow-up. We bring tomorrow’s precision oncology to today’s patients.

We usually deliver reports within two to three weeks. The results are precise, clearly structured, and can be directly integrated into therapy planning. Our analyses are based on the latest state of medical genetics and are continually updated in accordance with new scientific findings. If you have any questions regarding indications, sample material, or interpretation, our experts support you personally, competently and reliably

Your patients are insured in Germany? Our colleagues at the Zentrum für Humangenetik Tübingen will gladly support you!

We provide optimal support from diagnosis to monitoring with our somatic tumor analyses

Genetic Tumor Diagnostics

Keyvisual CancerEssential

CancerEssential® identifies key genetic alterations in common solid tumors such as lung, breast, or colorectal cancer quickly and reliably.

Using indication-specific gene sets, we analyze all relevant genes of a tumor type in a single step. This makes CancerEssential® an efficient diagnostic solution. The detection of specific mutations in tumor tissue forms the basis for selecting an approved targeted therapy.

Keyvisual CancerPrecision

CancerPrecision® provides a comprehensive molecular genetic profile of the individual tumor. This is the basis for personalized treatment decisions.

The analysis is based on a tumor–normal tissue comparison and precisely detects all genetic alterations that influence tumor behavior, therapy response, or resistance mechanisms – including key biomarkers such as MSI, TMB, and HRD. The medical report includes not only a comprehensive molecular genetic tumor profile, but also potential therapy options, supporting you in making informed, personalized treatment decisions.

Genetic Tumor Diagnostics

Add-Ons

In addition to CancerPrecision®

Keyvisual CancerFusionRx

CancerFusionRx® is the ideal complement to CancerPrecision® when a gene fusion is suspected of driving the tumor disease. Gene fusions are therapeutically relevant: therapies targeting these specific genetic alterations are being used with increasing frequency.

Using our unique method, we precisely detect therapy-relevant gene fusions at the RNA level. In the medical report, we provide all identified gene fusions along with a list of potential therapy options involving EMA- or FDA-approved drugs.

Specific Therapy Recommendations

Keyvisual CancerAdvice

CancerAdvice® provides well-founded therapy recommendations based on molecular genetic findings. Our interdisciplinary team of experts conducts the comprehensive research and evaluation of all relevant treatment options.

You receive clear recommendations on approved therapies (in-label), off-label options, and current clinical trials. All options are transparently categorized according to level of evidence, approval status (EMA/FDA), and study availability. In this way, we aim to support you in proposing the most suitable targeted treatment options for your patients.

Diagnostics for Personalized Immunotherapies

Keyvisual von CancerNeo

CancerNeo® supports you in the development of personalized cancer vaccines – for example, within clinical studies or individual therapy concepts.

Through comprehensive genetic analyses, we identify the most relevant somatic mutations and highly expressed target structures for an effective vaccine design.

Monitoring and Follow-Up

Keyvisual Cancer Monitoring

CancerMRD is a personalized and non-invasive monitoring approach used after completing tumor therapy. By monitoring minimal residual disease over time, our service enables to detect potential recurrences far earlier than traditional imaging and to asses therapy response reliably.

We initially create an individual tumor fingerprint based on tumor-normal tissue comparison. During follow-up, we examine blood samples for cell-free tumor DNA and compare the results with this profile. Blood collection is simple, can be repeated easily, and is particularly suitable for long-term disease monitoring.

Keyvisual of CancerDetect® panel

By analyzing cell-free tumor DNA from liquid biopsy, CancerDetect® detects the most common relevant hotspot mutations – for example, for therapy monitoring, early detection of resistance development, or diagnostics when no tumor tissue is available.

The simple, non-invasive sample collection enables reliable monitoring throughout the entire course of therapy.

Frequently Asked Questions

Topic-specific

The sooner, the better! The longer the life span of a tumor is, and the more therapies it outlasts, the more resistance mechanisms and survival strategies are developed by the tumor and the more difficult the treatment becomes. Ideally, a comprehensive genetic tumor analysis is performed after the first diagnosis. Knowledge about cancer-specific genetic alterations is crucial for choosing the best treatment.

Tumors acquire changes over time and with every therapy. To ensure that the genetic analysis provides the most recent molecular profile of the tumor, we strongly recommend analyzing the latest tumor tissue, e.g., after relapse or progression during or after treatment or new metastases. Thus, the analysis and the subsequent treatment decision made by an oncologist consider possible resistance and escape mechanisms that the tumor might acquire as a result of therapy. Please note that there is always the possibility of analyzing several tumor samples (e.g., Double Best Analysis). For further questions, please contact tumor@cegat.com.

In cases where resection of newly grown tumor mass is not possible because of a hard-to-access localization in the body or because a new operation is considered too risky for the patient, we offer an analysis of liquid biopsies (e.g., blood). In such cases, we ideally recommend the concurrent analysis of the available tumor tissue from original resection and a freshly obtained liquid biopsy sample. This approach enables robust tumor profiling based on the tumor tissue. Furthermore, that offers the chance to obtain a comprehensive and recent picture of the tumor’s genetic profile based on the analysis of the cfDNA.

For liquid biopsy analysis, special blood collection tubes are required. Please get in touch with us.

First of all, the sampling should not affect the course of therapy. Since this question is complex and cannot be answered in general, we recommend that you, as the treating physician contact us to discuss this in more detail. Please reach out to us at tumor@cegat.com.

Optimal treatment of a tumor can require adapting after a certain time. For example, the tumor might be able to adapt to the treatment by finding an escape mechanism. In such a case, a recurrence can happen, and treatment needs to be adapted. Therefore, a new sample should be analyzed to identify the changes that lead to tumor growth during treatment. Then, based on the latest findings, the treatment can be adjusted.

To separate somatic mutations from germline variants the individual germline variants need to be identified. When sequencing only tumor tissue this is done bioinformatically, but has been proven to result in a substantial number of mistakes. When sequencing the matched normal tissue sample (the sample from the same patient as the tumor tissue) the germline variants are directly identified, leaving no room for mistakes.

Sample Shipment & Costs

We provide sample collection boxes that contain instructions and the appropriate collection equipment. Also, the boxes can be used for shipment. The sample collection boxes are free of charge and can be ordered by email, mail, or phone. Depending on your needs, the following collection kits can be ordered from our logistics department:

  • EDTA kit (contains EDTA tube)
  • FFPE kit (contains Slidetrays for FFPE-slides and Bubble wrap for FFPE Block)
  • LB kit (contains Streck® tubes)
  • EDTA + FFPE kit (contains EDTA tube and Slidetrays for FFPE-slides and Bubble wrap for FFPE Block)
  • LB + EDTA kit (contains Streck® tubes and EDTA tube)

-> You can order the sample collection kits here.

The sample is sent to:

CeGaT GmbH
Paul-Ehrlich-Straße 23
D-72076 Tübingen
Germany .

It is processed in our own laboratory. Following the laboratory process, we prepare a medical report including individual recommendations for adapting your health care.

Are you insured in Germany? Our colleagues at the Zentrum für Humangenetik Tübingen will gladly support you!

-> Further information on sample material and shipping can be found here.

We are happy to provide prices on request. For German customers, we can also provide information regarding reimbursement. Don’t hesitate to get in touch with us at tumor@cegat.com.

Our tumor diagnostic service relies on high-quality data. However, sometimes the amounts or quality of tumor DNA is insufficient. In these cases, we request alternative sample material. If no alternative sample material is available, the analysis needs to be cancelled.

Please note: for our tumor diagnostic analyses a tumor content of 20% (or 0.5% for CancerDetect®) is a prerequisite. In certain cases like analyzing liquid biopsy or fresh frozen tumor tissue, the tumor content can be just determined after NGS. Samples with tumor content below 20% (or 0.5% for CancerDetect®) cannot be used for evaluation.

Result

After sample and payment receipt, our current turn around time (TAT) is 2-3 weeks. We require this time for sample processing in the lab (DNA Isolation, library prep, NGS), analysis of NGS data, and for our diagnostics team to examine the data and write the medical report.

Diagnostic Process

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Counseling & Test Selection

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Sampling & Shipment

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Sample Analysis

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Medical Report & Counseling

Further Information

Webinar: Discover the Power of Modern Tumor Diagnostics

Genetic tumor diagnostics can save lives

Downloads

Tumor Diagnostics Brochure (EN)
CancerPrecision Flyer (EN)
Application Note: A Smarter Way to Fish For Fusions
Specimen Guidelines for Tumor Diagnostics EN

Contact Us

Do you have a question, or are you interested in our service?

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Diagnostic Support

We will assist you in selecting the diagnostic strategy – for each patient.

Tumor team of CeGaT