Recent research suggests a close relationship between the composition of the human microbiome and the occurrence of a variety of diseases, including the response towards pharmaceutical drugs. According to recent findings, this relationship has been particularly shown for the gut microbiome, but it can also be extended to other body sites, such as the skin, mouth, or nose. Furthermore, microorganisms are involved in many biochemical reactions in the environment and represent important constituents of environmental ecosystems. Understanding microbial functions in specific microbiomes or host-microbe relationships, offers great potential for new therapeutic discoveries, especially for microbes, which are difficult to cultivate.
Shotgun metagenomic sequencing analyzes the complete DNA content of a sample and allows accurate detection of microbes (bacteria, archaea, fungi, protozoa, viruses, etc.) down to species level. Accordingly, functional genes encoding specific metabolic enzymes can be analyzed. Shotgun metagenomic sequencing is the best choice when microbiomes need to be thoroughly characterized, including accurate identification of microbial species and their functional repertoire.
Applications of shotgun metagenomic sequencing are diverse and include:
- Disease monitoring
- Microbial biomarker detection
- Drug development
- Characterization of environmental microbiomes
- Discovery of new microbial species (de novo assembly)
We offer different Shotgun Metagenomic Sequencing products to address a variety of research questions.