Analysis of epigenetic changes and their effects

Our Epigenomics Service

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Methylation Sequencing

Methylation matters: explore the epigenome

General Information about Our Epigenomics Service

The epigenome refers to the chemical modifications of the DNA and histone proteins that regulate the expression of genes. Epigenetic modifications are reversible and do not affect the DNA sequence itself. These changes control how well the DNA can be accessed and thus the gene expression level. Epigenetic mechanisms of gene regulation include changes in DNA methylation, modifications of histone tails, and expression of non-coding RNAs. These modifications can affect gene accessibility to DNA binding, regulatory proteins, and other components of the transcriptional machinery, ultimately altering transcription patterns.

As epigenetic modifications play a fundamental role in the gene expression, they are essential for the normal cell functioning. Changes in the epigenome can be associated with diseases such as cancer, autoimmune disorders, or neurological disorders.
Using state-of-the-art sequencing technologies, we help you to gain novel insights into functional consequences of epigenetic variations. With years of experience in the analysis of epigenetic modifications, we provide effective solutions for, e.g., DNA methylation detection and analysis.

Our Accreditations

Binding standards guarantee the quality of our work: our laboratory services are accredited according to CAP/CLIA and DIN EN ISO 17025. You can find further accreditations and certifications here.

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Knowledge Center

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Sequencing Services

Investigations at nucleotide level

Contact Us

Do you have a question or are you interested in our service? Feel free to contact us. We will take care of your request as soon as possible.

Start Your Project with Us

We are happy to discuss sequencing options and to find a solution specifically tailored to your clinical study or research project.

When getting in contact, please specify sample information including starting material, number of samples, preferred library preparation option, preferred sequencing depth and required bioinformatic analysis level, if possible.