Disease Prevention Panel

Understand genetic risk factors. Plan individual health care.

Every human being is unique. This fact also applies to the genetic predisposition to various diseases. If you know your potential risk factors, you can actively help to stay healthy or mitigate a disease.

The analysis of specific genes for potentially disease-causing variants enables us to identify health risks early and thus helps to initiate targeted preventive measures. For example, we examine genes that increase the risk of thrombosis, or heart disease or we determine whether there is a genetic predisposition to a tumor disease. The result of the Disease Prevention Panel is a genetic guide to a healthier life!

Are you insured in Germany? Our colleagues at Zentrum für Humangenetik Tübingen will gladly support you!

The Advantages of Our Disease Prevention Panel

Analysis of >170 risk genes

Efficacy check for >100 drugs

Results to act on

Nine combinations of modules

Your Possibilities for Prevention

We offer nine different modules on genetic diseases, which can be selected individually or in combination.

Tumor Diseases

Early detection is a crucial factor in cancer treatment.

Cardiovascular Diseases

Vascular diseases can develop gradually, and heart diseases are often discovered too late.

Thrombosis & Coagulation Disorders

Thromboses can cause e.g., strokes and pulmonary embolisms.

Iron & Copper Storage Disorders

An early diagnosis of these diseases can minimize related complications.

Hypercholesterolemia

Elevated blood lipid values can favor heart attacks.

Glaucoma

Hereditary glaucoma can already occur in early phases of life.

Malignant Hyperthermia

Malignant Hyperthermia (anesthetic complication) is a rare, but potentially life-threatening complication.

Drug Metabolization

A pharmacogenetic analysis can lower the risk of drug side effects.

Diabetes

Familial diabetes mellitus can develop over years without symptoms appearing.

Four Reasons for CeGaT’s Disease Prevention Panel

Certified Laboratory

All samples are processed in-house. CeGaT’s laboratory is accredited according to CAP/CLIA and DIN EN ISO 15189 and ensures reliable results.

Long-Lasting Health

A genetic analysis by CeGaT can save lives. By identifying genetic predispositions, diagnoses can be made at an early stage, and measures that increase the quality of life and chances of survival can be taken in a timely manner.

Risk Genes in Focus

We only examine relevant genes that have been scientifically confirmed as risk genes and pose a risk of disease that can be reduced by timely detection or adequate prevention. You can find out which genes are examined here.

Comprehensive Analysis of Genes

Using next-generation sequencing, we analyze the sequences of the selected genes in their entirety and do not limit ourselves to so-called hotspot regions. This ensures that no relevant information is overlooked and provides you with reliable findings.

CeGaTs comprehensive analysis does not limit itself to so-called hotspot regions.

Figure 1: Compared to other providers, CeGaT analyzes the sequences of the selected genes comprehensively and does not limit itself to so-called hotspot regions.

Field Reports

Oliver S. has a genetic variant that increases the risk of thrombosis.

Oliver S., 45 years

Life style: activ in sports, high travel activity

Result: our preventive diagnostics identified the Factor V Leiden mutation in Oliver S., which increases the risk of thrombosis.

Consequence: Oliver S. is aware of thrombosis and takes preventive measures when he has to sit on a long-haul flight, for example.

“I now know that I have a genetic variant that increases my risk of thrombosis. As I travel a lot by plane, I now try to stand up and move around more during a flight to prevent thrombosis.”

Anna M., 32 years

Life style: conscious diet, normal sleep patterns, regular exercise

Result: Our preventive diagnostics revealed an increased tumor risk in Anna M. due to a variant in the BRCA1 gene. A genetic change in the BRCA1 gene increases the risk of developing breast and ovarian cancer, among other things.

Consequence: Anna M. has a detailed check-up every six months and is closely monitored.

“I now know about my predisposition and regularly have cancer prevention tests. Based on my results, my sister also got tested and found out that she is a carrier of the same variant. The test has helped us both.”

Anna M. hat ein erhöhtes Risiko an Brust- oder Eierstockkrebs zu erkranken.

Would you like to find out more about CeGaT’s Disease Prevention Panel based on other examples?

Find more field reports here

Early Detection Plays a Crucial Role, Especially in Tumor Diseases

Chances of surviving cancer depending on the stage and type of tumor at diagnosis

Figure 2: 5-year survival rate depending on the stage and type of tumor. If the tumor is detected early and has not yet metastasized (blue circle), the chance of survival is 87-100% higher than at a later stage when metastases have formed (red circle).1

For tumor diseases, the following applies: the earlier a tumor is detected, the better the prognosis. The figure illustrates this principle using different tumor entities. If the tumor is diagnosed during the early stages (local), the chance of surviving for five years or longer is 87% to 100%. Survival rates significantly decrease if the tumor is detected after it has metastasized. CeGaT‘s Disease Prevention Panel checks whether there is an increased risk of tumor disease, and therefore, extended early detection measures should be taken.

Each genetic analysis with CeGaT’s Disease Prevention Panel provides a detailed report containing the test results, the recommended next steps for the person seeking advice and details of the scientific methods used.

View sample report (PDF)

Our Experts

Which Genes Are Analyzed?

The individual modules of CeGaT‘s Prevention Panel contain genes that have been scientifically confirmed as risk genes and pose a risk of disease that can be reduced by timely detection or adequate prevention. The compilation of genes is based on the recommendations of the American College of Medical Genetics and Genomics (ACMG) and has been supplemented by our specialists with other known risk genes.

APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDKN2A, CHEK2, DICER1, EPCAM, FH, FLCN, KIT, MEN1, MET, MLH1, MSH2, MSH6, NF1, NF2, PALB2, PDGFRA, PMS2, POLD1, POLE, PTCH1, PTEN, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, STK11, TMEM127, TP53, TSC1, TSC2, VHL, WT1

ACTA2, ACTC1, ACVRL1, ALPK3, BAG3, BMPR2, CALM1, CALM2, CALM3, CASQ2, COL3A1, DES, DSC2, DSG2, DSP, EMD, ENG, FBN1, FHL1, FLNC, GDF2, JUP, KCNH2, KCNK3, KCNQ1, LAMP2, LMNA, LOX, MYBPC3, MYH11, MYH7, MYL2, MYL3, MYLK, PKP2, PLN, PRKAG2, PRKG1, RBM20, RYR2, SCN5A, SMAD3, SMAD9, TBX4, TECRL, TGFB2, TGFBR1, TGFBR2, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR

ADAMTS13, F10, F11, F12, F13A1, F13B, F2, F5, F7, F8 (intronische Inversionen nicht beinhaltet), F9, GFI1B, GP1BA, GP1BB, GP6, GP9, HRG, ITGA2B, ITGB3, LMAN1, MCFD2, NBEAL2, PROC, PROS1, SERPINC1, SERPIND1, SERPINF2, VWF

ATP7B, CP, GLRX5, HAMP, HFE, HJV, SLC40A1, TFR2

APOB, LDLR, LDLRAP1, PCSK9

ABCG2, CACNA1S, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, G6PD, HLA-A, HLA-B, IFNL3, MT-RNR1, NUDT15, POR, RYR1, SLCO1B1, TPMT, UGT1A1, VKORC1

GCK, HNF1A, HNF1B, HNF4A, PDX1

General Information

Genetic Counseling

Our genetic counseling provides detailed information to those seeking advice about their genetic testing options and further procedures. During the consultation, we also discuss which genes can be analyzed. We want to ensure that all relevant questions are answered and that people seeking advice can make informed decisions about their health.

Genetic Analysis and Result

Our in-house laboratory analyzes the genes using an advanced technology called next-generation sequencing, or NGS for short. To do this, we isolate the DNA from the cells in the blood sample (figure 3) and then read the individual building plan of the DNA step by step (sequencing). We do not limit ourselves to so-called hotspot regions. Instead, we read the genes in their entirety.

The sequenced information is then analyzed in-house. We investigate whether particular characteristics or changes (variants) in the genes are associated with an increased risk of disease and play a role in individual health care. We compile the results in a report and conclude by explaining what significance this could have for the health of the person seeking advice.

Further details on sample material and shipment can be found here.

Diagnostic process for the Prevention Panel

Figure 3: Diagnostic procedure — from genetic analysis to the report.

Knowledge Center

Learn more about hotspots, NGS and other topics in our Knowledge Center.

Further Information

Dr. Stefanie Wendel (M.D.) talks about the advantages and possible applications of the Disease Prevention Panel.

Frequently Asked Questions

Before Choosing a Test

Preventive diagnostics is for individuals who want to personalize their preventive healthcare. The analyzed diseases don’t need to have already occurred in your family. On the contrary, a different type of analysis may be more suitable if you already have a family history of a certain disease. We will be happy to advise you on this.

This test is a predictive genetic analysis, which means that healthy individuals are tested for diseases that may occur in the future. For this reason, comprehensive counseling with a specialist in human genetics and a declaration of consent after the consultation, if necessary after a reflection period, are absolute prerequisites. We offer genetic counseling. Our specialist in human genetics will provide you with all the relevant information you need to make a decision about genetic testing.

Genetic counseling is a detailed consultation session with a specialist in human genetics in which all your questions about genetics are discussed. Based on a structured family history with a pedigree of up to three generations, we can address your situation and point out possible analysis options. You then decide whether and to what extent you would like to order a genetic diagnostic test.
We can offer the consultation either in person on-site or in a video consultation. If your doctor already has the necessary qualifications, they are welcome to advise you and order the diagnostics from us.

If you cannot come to Tübingen, we gladly send you a sample collection kit. You can use this kit to have your sample taken by a local doctor (e.g., a family doctor) and then send it back to us.

When analyzing biomarkers in the blood, e.g., cholesterol or tumor markers, a disease state’s impacts are measured. The disease may have already occurred at this point.
With predictive diagnostics, we start much earlier: we examine healthy people. We determine whether and in which areas there is an increased risk of illness. We also give recommendations on how to prevent a severe illness best with appropriate early detection.

Healthcare can be designed individually only with the knowledge of your own genetic predispositions. This means that in health sectors with a heightened risk, you can

  • carry out targeted and close-meshed preventive examinations
  • take targeted measures to detect the onset of a disease as early as possible
  • possibly even take measures to prevent the onset of a disease altogether

Preventive genetic diagnostics is not covered by public health insurance. In the case of private health insurance, coverage depends on the type of insurance. You are welcome to clarify this with your insurance company in advance (you will receive a cost estimate from us for this purpose). If a medical indication for testing is identified during genetic counseling, genetic testing for a specific issue might be covered by health insurance.

Sample & Analysis

We need a blood sample from the person seeking advice for the test.
On request, we can send you a sample collection kit. You can use this kit to have your blood sample taken by your family doctor and then send it back to us.

The sample is sent to:
CeGaT GmbH
Paul-Ehrlich-Straße 23
D-72076 Tübingen
Germany .

It is processed in our own laboratory. Following the laboratory process, we prepare a medical report including individual recommendations for adapting your health care.

Are you insured in Germany? Our colleagues at the Zentrum für Humangenetik Tübingen will gladly support you!

The samples for the Prevention Panel are analyzed using next-generation sequencing (NGS). We analyze the entire exome. In simple terms, this includes all genes in your genetic constitution. More precisely, all known areas in your genetic constitution that are potentially disease-causing are analyzed. It is therefore a very comprehensive genetic test.

As part of the prevention panel, we examine all prevention-relevant genes that can increase the risk of cancer. In genetics, this is generally independent of the type of tumor. For example, variants in the BRCA1/2 genes are considered to be factors for an increased risk of developing breast and ovarian cancer. However, changes in these genes also occur in patients with prostate cancer, skin cancer, pancreatic cancer, and many other tumors. The genes included in our Prevention Panel are for example associated with tumors of the digestive tract (various forms of colon cancer, stomach cancer and pancreatic cancer), breast cancer, ovarian cancer, skin cancer, thyroid tumors, and endocrine tumors.

Result & Consultation

Preventive genetic diagnostics is always accompanied by genetic counseling with a medical specialist in this field. All questions are clarified before the analysis, and the appropriate test is discussed. After the analysis, we explain the results and recommendations. This means that you are guided through the entire process and have a contact person at your side for any questions about your results.
If your doctor is already qualified in genetic counseling, you can also seek her or his advice. Your doctor can then order the diagnostics from us. If this is not the case, feel free to contact us so that one of our medical specialists can advise you.

If your test result shows an increased risk of developing a disease, this does not indicate an inevitable fate. For the disease risks examined in this panel, preventive measures can be taken to avoid, delay, or detect the disease at an early stage. Early detection of the disease in question can also significantly improve treatment options. If you are found to be at increased risk for a specific illness, an individual prevention plan can be created based on your personal needs.

There are measures that can be taken for all diseases that are tested with the Prevention Panel. For most of the genes that we test, the aim is to delay the disease, prevent it, or detect it as early as possible. With appropriate prevention, one can contribute to preventing the disease from arising at all or at least significantly delaying its onset This prolongs a healthy life and improves the quality of life. In the case of tumor diseases, a suitable prevention program can lead to a tumor being discovered and treated at a very early stage. This can significantly improve the course of the disease and the chances of survival.

All results are based on the current state of research. Our scientists conduct detailed research into the variants found. These scientific sources are also named in your report, allowing you and your doctors to understand what our recommendations are based on.

You will receive the results and your report during the genetic counseling session. Here, you will also be able to discuss your results and ask any questions you may have. You can then share this report with other doctors at any time. We only send the results to the patient/person seeking advice themselves.

Storage and Data Protection

You can decide for yourself if your sample and data should be destroyed after the analysis or if we should keep them, for example, for additional tests for a longer period (normally 10 years). A respective declaration of consent is included in our consent form, which you fill out together with a medical specialist before an analysis can take place.

Preventive Healthcare for Companies

Companies and healthcare facilities rely on our many years of experience and expertise in genetic diagnostics.
Are you also interested in preventive healthcare for your employees?

Downloads

Order Form PRV
Sample Report PRV Panel
Brochure PRV Panel (EN)
Flyer PRV Panel (EN)

Contact Us

Do you have a question, or are you interested in our service?

Diagnostic Support

We will assist you in selecting the diagnostic strategy – whether as a person seeking advice or as a physician.