Discover the next frontier in transcriptomics: Spatial Transcriptome Sequencing (STS). This cutting-edge advancement in our sequencing service portfolio combines gene expression analysis with tissue morphology. It thereby uncovers insights previously beyond reach that help us understand the organization of cells and tissues in health and disease.
Why Does Tissue Context Matter?
The spatial arrangement of cells and their proximity to other cells or structures provides crucial insights into cellular function, cell type, and state. However, conventional single-cell RNA sequencing methods disrupt the tissue structure due to using single-cell suspensions. Thereby, spatial information gets lost. Spatial Transcriptome Sequencing addresses this limitation by preserving the spatial context and revealing information about the organization of cells and tissue. The method combines histological staining and imaging with state-of-the-art RNA sequencing technology allowing researchers to capture, analyze, and visualize gene expression.
Applications of Spatial Transcriptome Sequencing
Spatial Transcriptome Sequencing uncovers cellular arrangements and transcriptomic cell states and maps cellular functions and phenotypes. These insights make Spatial Transcriptome Sequencing applicable to several fields:
- tissue heterogeneity analysis: understand tissue complexity and classify regions based on expression profiles.
- neuroscience: uncover cellular diversity and organization in brain tissues to enhance to gain deeper knowledge of diseases like Alzheimer’s or ALS.
- cancer research: profile tumor heterogeneity, characterize the tumor microenvironment, and uncover new insights for immuno-oncology
- developmental biology: reconstruct pathways like embryonic development and tissue regeneration.
Ready to Explore How Spatial Transcriptome Sequencing Can Transform Your Research?
Spatial Transcriptome Sequencing complements CeGaT’s established transcriptomics solutions. Depending on the research question, we provide products in two resolutions: standard definition (SD) and high definition (HD). Our team is happy to advise you on the most suitable product for your research question. For detailed information, visit our website or contact our Research & Pharma Solutions team at rps@cegat.com.