Disease Prevention Panel

Thromboses can cause e.g., strokes and pulmonary embolisms.

An early diagnosis of these diseases can minimize related complications.

All samples are processed in-house. CeGaT’s laboratory is accredited according to CAP/CLIA and DIN EN ISO 15189 and ensures reliable results.

A genetic analysis by CeGaT can save lives. By identifying genetic predispositions, diagnoses can be made at an early stage, and measures that increase the quality of life and chances of survival can be taken in a timely manner.

We only examine relevant genes that have been scientifically confirmed as risk genes and pose a risk of disease that can be reduced by timely detection or adequate prevention. You can find out which genes are examined here.

Using next-generation sequencing, we analyze the sequences of the selected genes in their entirety and do not limit ourselves to so-called hotspot regions. This ensures that no relevant information is overlooked and provides you with reliable findings.

Figure 1: Compared to other providers, CeGaT analyzes the sequences of the selected genes comprehensively and does not limit itself to so-called hotspot regions.

Life style: activ in sports, high travel activity

Result: our preventive diagnostics identified the Factor V Leiden mutation in Oliver S., which increases the risk of thrombosis.

Consequence: Oliver S. is aware of thrombosis and takes preventive measures when he has to sit on a long-haul flight, for example.

“I now know that I have a genetic variant that increases my risk of thrombosis. As I travel a lot by plane, I now try to stand up and move around more during a flight to prevent thrombosis.”

Life style: conscious diet, normal sleep patterns, regular exercise

Result: Our preventive diagnostics revealed an increased tumor risk in Anna M. due to a variant in the BRCA1 gene. A genetic change in the BRCA1 gene increases the risk of developing breast and ovarian cancer, among other things.

Consequence: Anna M. has a detailed check-up every six months and is closely monitored.

“I now know about my predisposition and regularly have cancer prevention tests. Based on my results, my sister also got tested and found out that she is a carrier of the same variant. The test has helped us both.”

Figure 2: 5-year survival rate depending on the stage and type of tumor. If the tumor is detected early and has not yet metastasized (blue circle), the chance of survival increases to 87% to 100% compared to a later stage when metastases have formed (red circle).¹

For tumor diseases, the following applies: the earlier a tumor is detected, the better the prognosis. The figure illustrates this principle using different tumor entities. If the tumor is diagnosed during the early stages (local), the chance of surviving for five years or longer is 87% to 100%. Survival rates significantly decrease if the tumor is detected after it has metastasized. CeGaT‘s Disease Prevention Panel checks whether there is an increased risk of tumor disease, and therefore, extended early detection measures should be taken.

Our genetic counseling provides detailed information to those seeking advice about their genetic testing options and further procedures. During the consultation, we also discuss which genes can be analyzed. We want to ensure that all relevant questions are answered and that people seeking advice can make informed decisions about their health.

Our in-house laboratory analyzes the genes using an advanced technology called next-generation sequencing, or NGS for short. To do this, we isolate the DNA from the cells in the blood sample (figure 3) and then read the individual building plan of the DNA step by step (sequencing). We do not limit ourselves to so-called hotspot regions. Instead, we read the genes in their entirety.

The sequenced information is then analyzed in-house. We investigate whether particular characteristics or changes (variants) in the genes are associated with an increased risk of disease and play a role in individual health care. We compile the results in a report and conclude by explaining what significance this could have for the health of the person seeking advice.

Further details on sample material and shipment can be found here.