CeGaT Research & Pharma Solutions is further expanding its service portfolio using the PacBio SMRT technology and offering HiFi Panel Sequencing with long reads. Our long-read panels allow researchers to focus on essential genes in pharmacogenomics and look at areas of the genome that are difficult to sequence using the short-read sequencing technology.
Variants in genes encoding proteins with pharmacologically relevant functions can alter drug metabolism. These variants can also affect a patient’s response to therapy. Using PacBio’s long-read sequencing technology and the Twist Alliance Panels, we are helping researchers study these essential genes in pharmacogenomics. HiFi Panel Sequencing can also help scientists to uncover hard-to-detect regions, so-called “dark genes,” that may be relevant to complex diseases such as cancer.
Shedding light on the “dark genome” with HiFi reads
We perform HiFi Panel Sequencing (PAS) using long reads on our PacBio platform. PacBio’s single molecule real-time (SMRT) technology generates HiFi reads with 99.9% accuracy and lengths of up to 6 kb, providing a precise representation of the genetic information. To efficiently target and capture specific regions of interest, we offer two pre-defined Twist panels:
The first panel is the Twist Alliance Dark Genes Panel. It allows you to investigate almost 400 medically relevant genes that are challenging to sequence, including SMN1, SMN2, GBA, and LPA. These genes are associated with spinal muscular atrophy, Alzheimer’s disease, and cardiovascular diseases. The second panel is the Twist Alliance Long-Read PGx Panel. With this panel, you can examine 49 pharmacogenomic genes. This makes our HiFi Panel Sequencing products powerful tools for gaining deeper insights into the “dark genome” and pharmacogenomics.
We look forward to hearing from you and will gladly advise you. Our team is ready to guide you in selecting the optimal sequencing options for your project. Contact us at rps@cegat.com to learn how we can help you realize your research project.