Understanding the epigenome is key to unlocking new insights into biology, health, and disease. Methylation patterns play a crucial role in analyzing epigenomic changes. This is why we’re excited to introduce HiFi Methylation Sequencing, the latest addition to our Methylation Sequencing portfolio. This cutting-edge technology uncovers epigenetic changes without converting DNA bases like other approaches.
An Alternative Approach to Unlock Epigenetic Insights
Traditional methods of studying DNA methylation require DNA conversion during library preparation. This process costs valuable time and resources and can affect DNA integrity and data quality in the case of bisulfite treatment. HiFi Methylation Sequencing offers an alternative approach: It eliminates the need for DNA base conversion. Instead it analyzes the kinetics of base incorporation to detect methylated cytosines in CpG contexts. Our approach preserves the integrity of your DNA samples while providing highly reliable data about methylation patterns.
The Right Product for Your Project
Depending on your project’s needs, we will advise you on the best methylation sequencing approach to achieve exceptional results for your research project. In addition to this long-read sequencing method, we offer short-read sequencing using enzymatic cytosine conversion. This gentle treatment preserves DNA integrity, ensures higher library quality, and reduces bias in comparison to bilsufite treatment.
Please get in touch with us or visit our website for further information about our HiFi Methylation Sequencing and other solutions we offer.